New Study States Scientist Fabricated Items In Influential 2006 Dementia Paper Which Gave Big Pharma Billions In Taxpayer Funding Confirming Previous Claims

July 29. 2022

My tweet on Twitter.com

On January 10, 2022, I stated in a time stamped tweet on the social networking website Twitter.com, "Echinacea helps brain health and is good for dementia patients. However, there's still the amyloid problem."

One month after my tweet, a scientific study was launched regarding the influential 2006 research report/paper on the amyloid protein, which big pharma used to gain billions of dollars in taxpayer funding from world governments, then revenues for dementia drugs. This week it was revealed the 2006 research report/paper was "fraudulent" and contained "fabricated" and "manipulated" data, which benefited big pharma.

As stated previously on the site, I have been doing scientific research work for years regarding cancer, HIV/AIDS, Parkinson's, Alzheimer's and Sickle Cell, among other items. I've published items to this site that proved 100% true and correct, even on matters of disease (see: Site Exclusives).

By the grace of God my research work has been going extraordinarily well. However, it is being criminally impeded by criminals in Hollywood and those helping them at the FBI, in illegal conduct costing people their health and lives [The FBI Is Stonewalling Congress On Releasing FBI File In Madonna Human Rights Abuse Case (Congressional Documents)].

I'd have already fully produced and released the pharmaceutical drugs and medical inventions I've developed had these vile criminals in Hollywood and the FBI not criminally interfered, due to their sick, greedy obsession with stealing entertainment copyrights I'd written years prior to the forthcoming pharmaceutical patents (songs, music videos, movie scripts/synopsis, books, ect).

Vile pop singer, Madonna, and her cronies began stealing copies of these items I'd registered in the Library of Congress years prior, then through a bribe she issued, the FBI began helping her and Hollywood commit these serious intellectual property crimes, which is their way (Former FBI Directors Robert Mueller And James Comey Criminally Defrauded Florida Submarine Company Out Of Billions Of Dollars In Copyrights And Patents To Benefit Former Employer Lockheed Martin Then Stonewalled Congress Regarding It  and The FBI Sued For Stealing Hundreds Of Millions Of Dollars In Civil War Era Gold).

I've also been doing research work on the climate issue and items I stated proved true ( 'Doomsday Glacier' In Antarctica Under Imminent Risk Of Collapse Confirming Previous Claims and Yellowstone Floods In Unprecedented Climate Event Confirming Previous Site Claims).

My tweets on Twitter.com

Lack of funding has been a big problem after Madonna with the help of the FBI stole my aforementioned copyrights and $500,000 home through criminal fraud (and blacklisted me from working in the entertainment industry in America). However, I've made a lot of sacrifices these past few years and have been saving my money, and will get my pharmaceutical drugs and medical inventions completed and released. I've never given up and will not for any reason.

Currently, I'm working under terrible conditions in Miami, where I'm being criminally harassed by Hollywood and the FBI. My life has been threatened. They made murder attempts. My computers and other equipment I use to do my science research work/forthcoming patents has repeatedly and deliberately been damaged and some destroyed, during break-ins to my home and via malicious hacks over the internet).

I've stated it before and I shall again. They don't want you to get well, as there is more money in the public being sick (meaning repeat customers). As stated previously on the site, a group of people affiliated with the Obama Administration (and are now connected to the Biden Administration) threatened me over my science research work/forthcoming patents, angrily stating "we don't want anything cured" because people being sick is a "lucrative business" in "America." I'm not going to stop my  work though. So you can take your threats and shove them up your ugly, corrupt backsides...

STORY SOURCE

Critical elements of leading Alzheimer’s study possibly fraudulent

Sat 23 Jul 2022 12.57 EDT - Last modified on Sat 23 Jul 2022 12.59 EDT - The highly influential paper, first published in 2006, has helped guide billions of dollars in US federal research into the disease. Critical elements of one of the most cited pieces of Alzheimer’s disease research in the last two decades may have been purposely manipulated, according to a report in Science.

Alzheimer’s is the most common cause of dementia globally, according to the World Health Organization. The highly influential paper, which was published in Nature in 2006, has helped guide billions of dollars in US federal government research into Alzheimer’s, according to Science.

The study, which looked at cognitive decline in mice, proposed that a specific amyloid protein may be responsible for cognitive decline. The hypothesis has since dominated the field, and researchers have worked for years to understand the mechanism by which such proteins may lead to decline.

But a neuroscientist in Tennessee, Vanderbilt University professor Matthew Schrag, said in a Science article that he and other reviewers have identified as many as 10 papers on the protein that deserve deeper scrutiny. The report also cited other prominent researchers who have had difficulty replicating results of the studies on the specific proteins.

“I focus on what we can see in the published images, and describe them as red flags, not final conclusions,” he told Science, when revealing his role as a whistleblower. “The data should speak for itself.”

The heart of the matter is whether images in multiple papers were manipulated to better support a hypothesis, with the work of researcher Sylvain Lesné under particular examination. Lesné, an associate professor at the University of Minnesota, is now under investigation by the university.

https://www.theguardian.com

Blots on a field? A neuroscience image sleuth finds signs of fabrication in scores of Alzheimer’s articles, threatening a reigning theory of the disease

21 Jul 2022 - Neuroscientist and physician Matthew Schrag found suspect images in dozens of papers involving Alzheimer’s disease, including Western blots (projected in green) measuring a protein linked to cognitive decline in rats.

In August 2021, Matthew Schrag, a neuroscientist and physician at Vanderbilt University, got a call that would plunge him into a maelstrom of possible scientific misconduct. A colleague wanted to connect him with an attorney investigating an experimental drug for Alzheimer’s disease called Simufilam. The drug’s developer, Cassava Sciences, claimed it improved cognition, partly by repairing a protein that can block sticky brain deposits of the protein amyloid beta (Aβ), a hallmark of Alzheimer’s. The attorney’s clients—two prominent neuroscientists who are also short sellers who profit if the company’s stock falls—believed some research related to Simufilam may have been “fraudulent,” according to a petition later filed on their behalf with the U.S. Food and Drug Administration (FDA).

Schrag, 37, a softspoken, nonchalantly rumpled junior professor, had already gained some notoriety by publicly criticizing the controversial FDA approval of the anti-Aβ drug Aduhelm. His own research also contradicted some of Cassava’s claims. He feared volunteers in ongoing Simufilam trials faced risks of side effects with no chance of benefit.

So he applied his technical and medical knowledge to interrogate published images about the drug and its underlying science—for which the attorney paid him $18,000. He identified apparently altered or duplicated images in dozens of journal articles. The attorney reported many of the discoveries in the FDA petition, and Schrag sent all of them to the National Institutes of Health (NIH), which had invested tens of millions of dollars in the work.

But Schrag’s sleuthing drew him into a different episode of possible misconduct, leading to findings that threaten one of the most cited Alzheimer’s studies of this century and numerous related experiments.

The first author of that influential study, published in Nature in 2006, was an ascending neuroscientist: Sylvain Lesné of the University of Minnesota (UMN), Twin Cities. His work underpins a key element of the dominant yet controversial amyloid hypothesis of Alzheimer’s, which holds that Aβ clumps, known as plaques, in brain tissue are a primary cause of the devastating illness, which afflicts tens of millions globally. In what looked like a smoking gun for the theory and a lead to possible therapies, Lesné and his colleagues discovered an Aβ subtype and seemed to prove it caused dementia in rats. If Schrag’s doubts are correct, Lesné’s findings were an elaborate mirage.

Schrag, who had not publicly revealed his role as a whistleblower until this article, avoids the word “fraud” in his critiques of Lesné’s work and the Cassava-related studies and does not claim to have proved misconduct. That would require access to original, complete, unpublished images and in some cases raw numerical data. “I focus on what we can see in the published images, and describe them as red flags, not final conclusions,” he says. “The data should speak for itself.”...

https://www.science.org